by Silviu “Silview” Costinescu_ Buy Me a Coffee at ko-fi.com

Allow me to leak some of their more intimate shots

SOURCE

Pfizer Wuhan R&D Center was founded on October 8, 2010, becoming the first world’s top 500 enterprises settled in Wuhan Biolake.

The US Pfizer is transferring its medicine safety business from India to Wuhan, capital of central China’s Hubei, due to the advantages of talent resources and industry environment here.

Five years ago, Pfizer established an affiliate at Wuhan Biolake, a national biological industrial base, and greatly expanded its research and development scale and cooperative sectors in China. The Pfizer Wuhan R&D Center is an important base supporting Pfizer’s global data processing, quality control and medicine safety.

Pfizer has two world class R&D centers in China’s Wuhan and Shanghai, with business operations in over 300 cities. Pfizer’s China Research and Development Center has become one of the company’s seven major R&D centers worldwide.” – government website of the Hubei Province, China

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To be continued and updated

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by Silviu “Silview” Costinescu_ Buy Me a Coffee at ko-fi.com

I don’t know if they do it, because no independent researchers examine those swabs, but I have always pointed out that our overlords seem more concerned with testing than with vaccinating. Almost like the vaccines were the bait and tests were the switch. And now we also know they totally CAN do that.
Just follow the science below.

November 3, 2020

Researchers engineer tiny machines that deliver medicine efficiently

by Johns Hopkins University School of Medicine

Johns Hopkins Researchers engineer tiny machines that deliver medicine efficiently
A theragripper is about the size of a speck of dust. This swab contains dozens of the tiny devices. Credit: Johns Hopkins University.

Inspired by a parasitic worm that digs its sharp teeth into its host’s intestines, Johns Hopkins researchers have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body.

David Gracias, Ph.D., a professor in the Johns Hopkins University Whiting School of Engineering, and Johns Hopkins gastroenterologist Florin M. Selaru, M.D., director of the Johns Hopkins Inflammatory Bowel Disease Center, led a team of researchers and biomedical engineers that designed and tested shape-changing microdevices that mimic the way the parasitic hookworm affixes itself to an organism’s intestines.

Made of metal and thin, shape-changing film and coated in a heat-sensitive paraffin wax, “theragrippers,” each roughly the size of a dust speck, potentially can carry any drug and release it gradually into the body.

The team published results of an animal study this week as the cover article in the journal Science Advances.

Gradual or extended release of a drug is a long-sought goal in medicine. Selaru explains that a problem with extended-release drugs is they often make their way entirely through the gastrointestinal tract before they’ve finished dispensing their medication.

“Normal constriction and relaxation of GI tract muscles make it impossible for extended-release drugs to stay in the intestine long enough for the patient to receive the full dose,” says Selaru, who has collaborated with Gracias for more than 10 years. “We’ve been working to solve this problem by designing these small drug carriers that can autonomously latch onto the intestinal mucosa and keep the drug load inside the GI tract for a desired duration of time.”

Researchers engineer tiny machines that deliver medicine efficiently
When an open theragripper, left, is exposed to internal body temperatures, it closes on the instestinal wall. In the gripper’s center is a space for a small dose of a drug. Credit: Johns Hopkins University

Thousands of theragrippers can be deployed in the GI tract. When the paraffin wax coating on the grippers reaches the temperature inside the body, the devices close autonomously and clamp onto the colonic wall. The closing action causes the tiny, six-pointed devices to dig into the mucosa and remain attached to the colon, where they are retained and release their medicine payloads gradually into the body. Eventually, the theragrippers lose their hold on the tissue and are cleared from the intestine via normal gastrointestinal muscular function.

Taken from the original research annexes

Gracias notes advances in the field of biomedical engineering in recent years.

“We have seen the introduction of dynamic, microfabricated smart devices that can be controlled by electrical or chemical signals,” he says. “But these grippers are so small that batteries, antennas and other components will not fit on them.”

Theragrippers, says Gracias, don’t rely on electricity, wireless signals or external controls. “Instead, they operate like small, compressed springs with a temperature-triggered coating on the devices that releases the stored energy autonomously at body temperature.”

The Johns Hopkins researchers fabricated the devices with about 6,000 theragrippers per 3-inch silicon wafer. In their animal experiments, they loaded a pain-relieving drug onto the grippers. The researchers’ studies found that the animals into which theragrippers were administered had higher concentrates of the pain reliever in their bloodstreams than did the control group. The drug stayed in the test subjects’ systems for nearly 12 hours versus two hours in the control group.

“Swarms of microscopic robots that can be injected”
Tell Melinda Gates we can inject robots these days.

PubMed, 2015 Jun 9.:

Nanoneurotherapeutics approach intended for direct nose to brain delivery

Shadab Md  1 Gulam Mustafa  2   3 Sanjula Baboota  3 Javed Ali  3 Affiliations Expand

Abstract

Context: Brain disorders remain the world’s leading cause of disability, and account for more hospitalizations and prolonged care than almost all other diseases combined. The majority of drugs, proteins and peptides do not readily permeate into brain due to the presence of the blood-brain barrier (BBB), thus impeding treatment of these conditions.

Objective: Attention has turned to developing novel and effective delivery systems to provide good bioavailability in the brain.

Methods: Intranasal administration is a non-invasive method of drug delivery that may bypass the BBB, allowing therapeutic substances direct access to the brain. However, intranasal administration produces quite low drug concentrations in the brain due limited nasal mucosal permeability and the harsh nasal cavity environment. Pre-clinical studies using encapsulation of drugs in nanoparticulate systems improved the nose to brain targeting and bioavailability in brain. However, the toxic effects of nanoparticles on brain function are unknown.

Result and conclusion: This review highlights the understanding of several brain diseases and the important pathophysiological mechanisms involved. The review discusses the role of nanotherapeutics in treating brain disorders via nose to brain delivery, the mechanisms of drug absorption across nasal mucosa to the brain, strategies to overcome the blood brain barrier, nanoformulation strategies for enhanced brain targeting via nasal route and neurotoxicity issues of nanoparticles.

Epub 2013 Oct 16.

Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting

Hitendra S Mahajan  1 Milind S MahajanPankaj P NerkarAnshuman Agrawal Affiliations Expand

Abstract

The central nervous system (CNS) is an immunological privileged sanctuary site-providing reservoir for HIV-1 virus. Current anti-HIV drugs, although effective in reducing plasma viral levels, cannot eradicate the virus completely from the body. The low permeability of anti-HIV drugs across the blood-brain barrier (BBB) leads to insufficient delivery. Therefore, developing a novel approaches enhancing the CNS delivery of anti-HIV drugs are required for the treatment of neuro-AIDS. The aim of this study was to develop intranasal nanoemulsion (NE) for enhanced bioavailability and CNS targeting of saquinavir mesylate (SQVM). SQVM is a protease inhibitor which is a poorly soluble drug widely used as antiretroviral drug, with oral bioavailability is about 4%. The spontaneous emulsification method was used to prepare drug-loaded o/w nanoemulsion, which was characterized by droplet size, zeta potential, pH, drug content. Moreover, ex-vivo permeation studies were performed using sheep nasal mucosa. The optimized NE showed a significant increase in drug permeation rate compared to the plain drug suspension (PDS). Cilia toxicity study on sheep nasal mucosa showed no significant adverse effect of SQVM-loaded NE. Results of in vivo biodistribution studies show higher drug concentration in brain after intranasal administration of NE than intravenous delivered PDS. The higher percentage of drug targeting efficiency (% DTE) and nose-to-brain drug direct transport percentage (% DTP) for optimized NE indicated effective CNS targeting of SQVM via intranasal route. Gamma scintigraphy imaging of the rat brain conclusively demonstrated transport of drug in the CNS at larger extent after intranasal administration as NE.

Similar articles

PubMed Epub, 2016 Jun 28:

Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery

Sara Salatin  1   2 Jaleh Barar  1   3 Mohammad Barzegar-Jalali  3 Khosro Adibkia  3   4 Mitra Alami Milani  2   4 Mitra Jelvehgari  5   6 Affiliations Expand

Affiliations

  • 1 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran.
  • 2 Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
  • 3 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Mailbox 51664, Tabriz, Iran.
  • 4 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 5 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Mailbox 51664, Tabriz, Iran. mitra_jelvehgari@yahoo.com.
  • 6 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. mitra_jelvehgari@yahoo.com.

Abstract

Over the past few years, nasal drug delivery has attracted more and more attentions, and been recognized as the most promising alternative route for the systemic medication of drugs limited to intravenous administration. Many experiments in animal models have shown that nanoscale carriers have the ability to enhance the nasal delivery of peptide/protein drugs and vaccines compared to the conventional drug solution formulations. However, the rapid mucociliary clearance of the drug-loaded nanoparticles can cause a reduction in bioavailability percentage after intranasal administration. Thus, research efforts have considerably been directed towards the development of hydrogel nanosystems which have mucoadhesive properties in order to maximize the residence time, and hence increase the period of contact with the nasal mucosa and enhance the drug absorption. It is most certain that the high viscosity of hydrogel-based nanosystems can efficiently offer this mucoadhesive property. This update review discusses the possible benefits of using hydrogel polymer-based nanoparticles and hydrogel nanocomposites for drug/vaccine delivery through the intranasal administration.

Keywords: Brain; Hydrogel; Nanoparticles; Nasal delivery; Vaccine.

Similar articles

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by Silviu “Silview” Costinescu_ Buy Me a Coffee at ko-fi.com

In my latest article I dared everyone to find out the identity of Klaus Schwab’s parents (the mastermind behind WEF / The Great Reset). No one has provided so far, the call is still open for all researchers. But at least I’m now able to prove who his spiritual parent is and how that falls in the grand scheme.

Since the first day I got introduced to Klaus Schwab’s Great Reset I’ve seen Kissinger’s fingerprints all over it, but I had no hard evidence. Now we have it.
Second question that arose upon research was how did this engineer become the prime-minister of world’s shadow government? I’ve seen much brighter people die in misery. I see his main financial backing was from Rothschilds / World Bank, is/was his mother a Rothschild maybe? We can only speculate since he erased his family from Internet records.
But this video I’ve just unearthed (taken from a conference in Singapore, in 2016) cements him near Soros and Kissinger, as part of the ideological and executive triad that engineered the Rothschild – China alliance. As I’ve shown in a previous article, this alliance is at the core of the high-tech-globalist-communist regime that’s being rolled over the world right now under The Great Reset / Fourth Industrial Revolution brands and under the Covid-19 pandemic as a cover. Even the #Kraken can be traced back to them.
Below is the rest of the illustrated scheme. I tried to keep it as brief as possible, which was not an easy task given the abundance of ignored evidences.

Read
From South China Morning Post
Chinese Premier Li Keqiang greets Klaus Schwab during 2017’s WEF in China
Who said #Kraken?

Aaand the answer to our headline question is:

UPDATE:
The new culmination of this global power reset:

Read: HUGE! TRUMP’S JUST OUSTED KISSINGER FROM THE PENTAGON DEFENSE POLICY BOARD, SEVERING MORE TIES WITH CHINA AND GLOBALISTS

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by Silviu “Silview” Costinescu

UK’s Government’s Medicines & Healthcare products Regulatory Agency (MHRA) spends close to $2million on an Artificial Intelligence to monitor “Medicines & Healthcare products Regulatory Agency”. If this isn’t alarming, I don’t know what is. But I know there’s more to the story.

The MHRA urgently seeks an Artificial Intelligence (AI) software tool to process the expected high volume of Covid-19 vaccine Adverse Drug Reaction (ADRs) and ensure that no details from the ADRs’ reaction text are missed.

MRHA
DOWNLOAD PDF

Thanks Graham Pick for the tip!

The acquisition document further provides this explanation:

“For reasons of extreme urgency under Regulation 32(2)(c) related to the release of a Covid-19 vaccine MHRA have accelerated the sourcing and implementation of a vaccine specific AI tool.

Strictly necessary — it is not possible to retrofit the MHRA’s legacy systems to handle the volume of ADRs that will be generated by a Covid-19 vaccine. Therefore, if the MHRA does not implement the AI tool, it will be unable to process these ADRs effectively. This will hinder its ability to rapidly identify any potential safety issues with the Covid-19 vaccine and represents a direct threat to patient life and public health.

Reasons of extreme urgency — the MHRA recognises that its planned procurement process for the SafetyConnect programme, including the AI tool, would not have concluded by vaccine launch. Leading to a inability to effectively monitor adverse reactions to a Covid-19 vaccine.

Events unforeseeable — the Covid-19 crisis is novel and developments in the search of a Covid-19 vaccine have not followed any predictable pattern so far.”

Beneficiary of this contract is a company named Genpact, part of a larger multi-industry group with the same name.
Genpact also does Facebook moderation, which gives it access to Facebook data!

Source

Genpact CEO is close to our old friends from WEF, of course

Here he supports using military to distribute the vaccine that will then provide work for his company:

He seems to applaud a Biden victory in the US presidentials. :

This Tyger dude basically has all the traits and inclinations of the elite mafia that set up Covidiocracy as the new business and live-stock management model for the whole world.

Source

Genpact has acquired 23 companies, including 10 in the last 5 years. A total of 8 acquisitions came from private equity firms. Genpact’s largest acquisition to date was in 2011, when it acquired Headstrong for $550MGenpact has acquired in 11 different US states, and 5 countries. The Company’s most targeted sectors include information technology (28%) and software (28%). – Mergr

Gentec CEO interview

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by Silviu “Silview” Costinescu_ Buy Me a Coffee at ko-fi.com

The producer behind “Armageddon,” “The Purge” and “A Quiet Place” has released a trailer for his upcoming feature film “Songbird.” It predicts a dire, snowballing disease mutation — COVID-23 — that has created a horrific hellscape by 2024. But to me, first thing it reminded of is one of the first videos I edited for Silview.media. So I put them together in a new video.

For further details on the Gates productions, readt our earlier feature:
EXCLUSIVE: BILL GATES BEHIND MTV’S “HOLOCAUST HAPPENED TO PEOPLE LIKE US”. PREDICTIVE PROGRAMMING?

Songbird is billed as a “terrifying thriller” and the “first feature film to be made during COVID-19 in Los Angeles, and about the pandemic itself”. The official press-release reads:

“The COVID-23 virus has mutated and the world is in its fourth year of lockdown. Infected Americans are ripped from their homes and forced into quarantine camps known as Q-Zones, from which there is no escape, as a few brave souls fight back against the forces of oppression.”

In July, the movie was hit with a “do not work” order from the Screen Actors Guild – American Federation of Television and Radio Artists (SAG-AFTRA) because of concerns about coronavirus safety protocols.

And the first question it raised to me was: Predictive programming?

UPDATE

Looks like my instincts don’t lie, if I know how to listen

Source
Source

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by Silviu “Silview” Costinescu_ Buy Me a Coffee at ko-fi.com

This makes my blood boil, so I will refrain from more comments in this state, here are the facts.

A new study estimates the pandemic could cause over 400,000 deaths in the U.S. this year. It includes those who died of COVID-19 and people who died due to disruptions caused by the pandemic, NPR reports.
Just more fill-up for their FearPornHub, I thought. At first I couldn’t care about any more of this type of inane drivel, knowing the virus hasn’t been isolated and purified as per Koch’s postulates, they have no tests for Covid, thus they can’t to come up with any statistics, so it’s all just marketing mambo-jumbo to cover for The Great Reset and The Fourth Industrial Revolution, their official names for Covidiocracy.
BUT
One sequence made my red light blink. On review, it blew up my BS detectors:

ALCA: So why the discrepancy between the numbers they’re getting and the numbers that are being reported? Well, they think there are two reasons. Woolf says one of the reasons is that some people just aren’t having COVID-19 listed on their death certificates.
STEVEN WOOLF: The second is people who do not have COVID-19 but die because of disruptions caused by the pandemic. So an example would be somebody has chest pain. They’re scared to call 911 because they don’t want to get the virus, and they die of a heart attack.
CHANG: OK, but that’s not the same as dying from COVID-19.
PALCA: No, but if you’re trying to estimate the burden of the pandemic on American health and the nation’s health, then it’s certainly reasonable to count those kinds of deaths as related to – as blaming them on the pandemic.

So now, let’s say if I return to hunger-strike to protest their lies and literal terrorism, and if I die as a result of the protest, then I end up on their list and they will use me to sell more Covidiocracy.
This kinda leaves me no choice other than to make sure I die AFTER I eliminated Covidiocracy.

Below you have the full transcript of the NPR report:

AILSA CHANG, HOST:

The total number of deaths related to COVID-19 in this country could top 400,000 by the end of the year. That’s according to a study out today in the medical journal JAMA. Four hundred thousand is about the number of Americans who died in World War II. Joining me now to talk about how researchers came up with this number is NPR science correspondent Joe Palca. Hey, Joe.

JOE PALCA, BYLINE: Hi, Ailsa.

CHANG: So, you know, we’ve been reporting that the number of COVID deaths is a bit more than 200,000 now. I don’t get it. Is that number actually going to double by the end of the year?

PALCA: Well, no because the study out today suggests that there’s an undercounting of deaths that could be related to COVID-19. Let me explain. So Steven Woolf is director of the Center on Society and Health at Virginia Commonwealth University, and he and his colleagues looked at deaths from all causes this year and compared those to historical death rates. And this year was higher, so they figured that the explanation is COVID-19 because that’s been the main difference in the health situation.

CHANG: Right.

PALCA: So why the discrepancy between the numbers they’re getting and the numbers that are being reported? Well, they think there are two reasons. Woolf says one of the reasons is that some people just aren’t having COVID-19 listed on their death certificates.

STEVEN WOOLF: The second is people who do not have COVID-19 but die because of disruptions caused by the pandemic. So an example would be somebody has chest pain. They’re scared to call 911 because they don’t want to get the virus, and they die of a heart attack.

CHANG: OK, but that’s not the same as dying from COVID-19.

PALCA: No, but if you’re trying to estimate the burden of the pandemic on American health and the nation’s health, then it’s certainly reasonable to count those kinds of deaths as related to – as blaming them on the pandemic.

CHANG: OK. So I take these numbers are for the U.S. as a whole, but are there regional differences when it comes to the impact of COVID?

PALCA: Yes, there were. In fact, states like New York and Massachusetts and Connecticut that responded aggressively when they saw their excess death rates ramp up at the start of the year also saw them come back to normal historical levels in about May – so about seven or eight weeks later. But states that never brought their outbreaks under control – they still continue to see a surge in these excess deaths, suggesting that public health measures was a big part in controlling things.

CHANG: And do we have any idea whether these excess deaths, as you call them, from the pandemic are showing up in other countries?

PALCA: Yes, this is a pattern that scientists are seeing in other countries. But there’s an interesting twist. So there’s a paper also being published in JAMA that compares how the excess death rates in the United States due to the pandemic compare to death rates in other countries that were hit hard like Italy and Spain and France. And remember; these are rates, not actual numbers because these are different-sized countries.

Ezekiel Emanuel of the University of Pittsburgh is a co-author of that study. And he says at the start of the year, the excess deaths in those countries were fairly comparable with the United States. But then they started dropping down to levels closer to what they were before the pandemic. And Emanuel says that wasn’t the case in the U.S. So what those countries – so what were those countries doing that we weren’t doing?

EZEKIEL EMANUEL: They didn’t have a vaccine that we didn’t have. They didn’t have some special cocktail treatment that we didn’t have. The difference is how conscientiously did we implement public health measures – physical distancing, masks, keeping crowds small, not moving inside for social gatherings? And we performed poorly.

CHANG: So is it possible to do better at this point and improve the situation here in the U.S.?

PALCA: Yes. Both Emanuel and Steven Woolf from Virginia Commonwealth University say that implementing those measures that Emanuel was just talking about would make a big difference, and the death rate could come down significantly by the end of the year. And a vaccine will help. Although when we get the vaccine and who will be able to get it, that’s a topic for another day.

CHANG: That’s NPR’s Joe Palca. Thank you, Joe.

PALCA: You’re welcome.


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by Silviu “Silview” Costinescu_ Buy Me a Coffee at ko-fi.com

Never believe what we say, always research what we say.
As for CDC, if you research what they say you end up finding out they have 85% failure rates.

This is the recent CDC report, in PDF format, sourced from the CDC website.
And below is my sufficient commentary in visual form. There’s nothing else to say, the official narrative is dead and buried, at this point we’re just burning calories if we keep flogging it.

PS: #stopstealingoxygen

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by Silviu “Silview” Costinescu_ Buy Me a Coffee at ko-fi.com

Just an idea and some memes

#STOPSTEALINGOXYGEN
#STOPSTEALINGOXYGEN

SHARE THE MEMES

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by Silviu “Silview” Costinescu_ Buy Me a Coffee at ko-fi.com

This just happened. And much more. As we’ve warned you since March, but people thought WHO can take better care of them. OK then…

It’s World Mental Health Day!
-Close to 1 billion people have a mental disorder
-Depression is a leading cause of illness & disability
-1 person dies every 40 seconds from suicide
-3 million people die every year due to harmful use of 🍻#MoveForMentalHealth: Let’s invest!

WHO

Meanwhile at CDC:

How did we end up here:

Me, March 2020:

The caring people: meh

Everyone in April:

Source

The caring people: meh

And so forth gradually building up until The Daily Telegraph and Sky News Australia ended up talking about “harrowing statistics” today:

Source

“Very sadly, more boys under the age of 18 in nine-months alone, than we’ve ever seen in Victoria over a full 12-month period have taken their life this year,”

Sky News

Per coincidence as ever, the suicide rates among Victoria’s teenagers are up over 30% this year, just like among US Army soldiers. I wonder what they had in common, right?

Army active-duty suicides are up 30% during the same time frame as COVID-19.

ABC News, October 2020

The caring people: meh

These “meh people” are the same ones who loudly and aggressively act as if they are entitled to free heaith care (mask-wearing) from their victims. How about some warm flegm instead?


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